A mechanism for the hydroperoxide-mediated inactivation of prostacyclin synthetase.
نویسندگان
چکیده
Hydroxyl radical generation was demonstrated during heme-catalyzed decomposition of 15-hydroperoxy arachidonic acid. The hydroperoxide-mediated inactivation of prostacyclin synthetase seems to be related to the generation of this highly reactive species. A relationship between hydroperoxides and the hydroxyl radical may be important in the modulation of prostacyclin synthesis in diseased states.
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ورودعنوان ژورنال:
- Blood
دوره 53 6 شماره
صفحات -
تاریخ انتشار 1979